Receptor Bias and Potency in Incretin Peptide Research
How to compare potency, efficacy and signalling bias across GLP-1, GIP and glucagon receptor assays without overinterpreting platform effects.
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The North Specs research library
Cited briefings on peptide science, analytical methods, Canadian research requirements and reproducible laboratory practice.
For qualified research audiences. This library is educational, not medical advice or a protocol for human or veterinary use.
All briefingsRegional ResearchCompound BriefingsAnalytical MethodsExperimental DesignCanada & RegulationMetabolic ResearchStability & HandlingResearch LandscapeMethodologyTissue RepairLongevity ResearchBioregulation & Signalling
Albumin Binding and Acylated Peptides: A Research Methods Guide
Why fatty-acid modification and albumin binding change peptide exposure, free concentration, assay recovery and interpretation.
Read briefingGlucagon Receptor Experiments in Triple-Agonist Research
How to study glucagon receptor activity within triple-agonist programmes, including receptor balance, selectivity, species effects and safety-related endpoints.
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GIP Receptor Pharmacology: Why the Experimental Context Matters
A guide to GIP receptor biology, agonism and antagonism, with emphasis on species, receptor expression and matched functional assays.
Read briefingGLP-1 Receptor Assay Design: Controls, Curves and Interpretation
A practical guide to designing GLP-1 receptor assays, including receptor reserve, reference agonists, albumin, adsorption and curve analysis.
Read briefingRetatrutide, Tirzepatide and Semaglutide: How to Compare the Research
A method-first comparison of semaglutide, tirzepatide and retatrutide that separates receptor design, trial populations and regulatory status.
Read briefingRetatrutide: What Triple-Agonist Research Shows So Far
A focused review of retatrutide as a GIP, GLP-1 and glucagon receptor agonist, from phase 1b and phase 2 trials to structural…
Read briefingTirzepatide and Dual GIP/GLP-1 Receptor Agonism
A mechanistic and evidence-led review of tirzepatide as a dual GIP and GLP-1 receptor agonist, with guidance for laboratory assay design.
Read briefingOzempic in 2017: What the First FDA Approval Changed for GLP-1 Research
A historical review of the 2017 Ozempic approval and the research questions it opened for long-acting GLP-1 receptor agonists.
Read briefingSemaglutide: From Peptide Engineering to FDA and Health Canada Milestones
A scientific timeline of semaglutide, focusing on peptide engineering, receptor pharmacology, pivotal evidence and regulatory milestones.
Read briefingAI Search for Peptide Literature: A Reproducible Review Workflow
A practical workflow for combining AI-assisted discovery with PubMed, Crossref, registered queries and human verification in peptide evidence reviews.
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PT-141 and Melanotan II: Melanocortin Receptor Selectivity
A receptor-level comparison of PT-141, melanotan II and melanocortin signaling, with controls for pathway selectivity and pigment-related readouts.
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